PSEG Nuclear uses a deterministic screening process to risk-score individual Equipment Reliability (ER) issues by probability and consequence. The resulting issues are displayed on a matrix called the Heat Map. Consequence attributes are primarily driven by production and nuclear safety. While several of these attributes (e.g., Maintenance Rule safety significance, Mitigating System Performance Indicator or MSPI equipment) are adequate surrogates for actual Probabilistic Risk Assessment (PRA) information, none directly measure severe accident risk increases. In late 2020, the PSEG Board of Directors challenged PSEG Nuclear to apply a risk-informed method to prioritize Heat Map issues based on ‘Intersecting Vulnerabilities.’ An intersecting vulnerability is a situation where a higher risk results from the aggregation of related issues versus the individual risk from each of these issues. Industry benchmarking indicated that this would be a first-of-a-kind application of PRAs. A pilot project was implemented to determine the feasibility of an approach that includes mapping existing Heat Map issues into the PRA models, calculating meaningful risk estimates, determining when those estimates indicate a potential intersecting vulnerability and communicating the results to plant management. This approach, after some adjustments, is currently being used to evaluate Heat Map issues and has identified several instances of intersecting vulnerabilities.