On behalf of the nuclear energy industry, the Nuclear Energy Institute (NEI)1 is pleased to submit the attached comments to the Department of Energy’s (DOE) Request for Information (RFI) regarding the establishment of a program to support the availability of High-Assay Low-Enriched Uranium (HALEU) for civilian use. In 2020, the DOE made two awards under the Advanced Reactor Demonstration Program (ARDP) demonstration pathway, five awards under the risk reduction pathway, and three under the ARC-20 program. Most of these designs will require HALEU and fuel forms very different from those manufactured for the current light water reactors (LWRs). This RFI is a critical step in supporting the deployment of domestic HALEU capabilities and regaining U.S. leadership in nuclear energy and the supply chain.